Exenatide/Methylcobalamin (Byetta with B12)

Weight Loss / Pre Diabetes / Diabetes / Insulin Resistance / Blood Sugar Control

Why should I use Exenatide (Byetta) for weight loss?

Exenatide (Byetta), a drug normally used to treat diabetes, also helps non-diabetic obese people lose weight when combined with diet and exercise. Exenatide seems to promote weight loss by causing people to eat less and increasing feelings of fullness. Of interest, a consistent finding in large clinical studies is that hemoglobin A1C levels (measured for diabetes control) declined but then plateaued while weight loss continued. Indicating that it is safe to use for continued weight loss with low risks of hypoglycemia.

  • FAQs

Why is Vitamin B12 added to the injection?

Vitamin B12 is not a normal part of Byetta. It’s added specially to Exenatide for you by my certified compounding pharmacy. Vitamin B-12 has been implicated to give you more energy and boost your metabolism so it can add the exenatide in working. 

How do you take Exenatide?

Inject this medication under the skin in the thigh, abdomen, or upper arm as directed by your doctor, usually twice a day. The injections should be done within 60 minutes before the morning and evening meals (or before the two main meals of the day, at least 6 hours apart). Exenatide should not be used after a meal since it will not work as well. Dosage is usually 5mg subcutaneous twice daily and can be titrated up to 10mg subcutaneous twice daily in some people. 

What are the possible side effects of Exenatide?

Nauseavomitingdiarrhea, nervousness, or upset stomach may occur as your body adjusts to the medication. Nausea usually lessens as you continue to use exenatide. Other side effects include decreased appetite or weight loss. Although exenatide by itself usually does not cause low blood sugar (hypoglycemia), low blood sugar may occur if this drug is prescribed with other diabetes medications.  

Symptoms of low blood sugar include sudden sweating, shaking, fast heartbeat, hungerblurred visiondizziness, or tingling hands/feet. It is a good habit to carry glucose tablets or gel to treat low blood sugar. Raisins, honey, or jelly can work well too.  

Exenatide has rarely caused a very serious (possibly fatal) disease of the pancreas (pancreatitis). Get medical help right away if you develop symptoms of pancreatitis, including nausea/vomiting that doesn't stop, and/or severe stomach and abdominal pain.

Who should not take Exenatide?

Exenatide is not recommended for use in patients with end-stage renal disease or severe renal impairment (creatinine clearance <30 mL/min) and should be used with caution in patients with renal transplantation.

What else do I need to know about Exenatide?

Since exenatide slows down the digestion of food and drugs in your stomach, certain medications (such as birth control pills and antibiotics taken by mouth) may not work as well if you take them at the same time. Take birth control pills or antibiotics at least 1 hour before using exenatide. If you must take these medications with food, take them with a meal or snack when you do not also take exenatide. 

Limit alcohol while taking this medication because it can increase your risk of developing low blood sugar.

What do I need to do before getting on Exenatide?

Contact Barbara Grubbs for an appointment to discuss the medication and your goals. We will review your medical history and order lab work. Once your lab work comes back we can arrange to get you started on Exenatide. 

How do I get an appointment?

Schedule online yourself easily. I’m also available at barbaragrubbs@telemedicinepractitioners.com and via text at 803.900.5758. Text me for a work-in if you can’t find the right availability on my online calendar.

This is a prescription drug that requires I have special licensing in your state to prescribe it to you. I’m licensed in SC*, FL, NM, AZ, IA, CO, MI, NV, VA, UT, ID, OR, RI, CT, WA, MI, DC.

A lot of videos explain and show this on youtube. I also have instructions HERE.

What Clients Say

“I went from 304 pounds to 260 pounds since April 15th, 2018. It is now December. Hope to lose at least another 60 pounds or more. Works great for me!”


“I was put on Byetta about two years ago, it had helped lower my blood sugar as well as my A1C level, not to mention it's helped me lose a lot of weight.”


“I've been on it for two full months.I started with 5mg for a month then 10mg for the second month. I'm starting my 2nd 10mg pen and my third month. I've experienced some loose stools during the first two weeks then back to normal. I've had no other adverse effects and my sugar has gone down from the 230 range to the 150 range and hopefully still dropping. My weight has gone from 365 to 340. I noticed that I don't want to eat as much, the effect is very subtle but I've learned to recognize it and I just push away from the table. So far everything's thumbs up.”


“After starting the Byetta (Exenatide) it was about 3 weeks and I started to notice weight loss. I gradually lost my desire to eat sweets all the time, and started staying awake more and more”


“I only had one thing that I wasn't pleased with and that was nausea, it was very intense for about 2 weeks then it subsided. It was a great weight loss. I find the advantages of the drug well worth the side effects. I feel that I have more control over my blood sugar than I have in ten years!! I wish I was aware of it sooner. Just not knowing what my high readings have done to some of my vital organs is scary. I feel now that I'm on the right track and I finally have peace of mind about my health.”


“I’ve been on it for 1 week and have lost 4LBS. no sickness, sugars are 1/2 what they were. injections hurt far less than lancets! miracle drug for my type 2. appetite is 1/4th what used to be. I'm looking forward to my next A1c.”  




Barbara Grubbs is a telehealth provider dedicated to offering comprehensive advice and consultation to patients from the comfort of their homes. She helps people with Weight loss / anti-aging / wellness / peptides.

Barbara's commitment to telehealth is rooted in her belief that accessible healthcare can lead to better health outcomes. Her approach is patient-centric, aiming to reduce the barriers to medical care by providing timely and accurate consultations. Whether managing chronic conditions, addressing acute concerns, or offering preventive care advice, Barbara Grubbs is a reliable resource for patients seeking quality healthcare remotely.

"I've worked in weight loss and healthcare wellness for over 20 years! I'm passionate about improving your QUALITY of life and preventing illness before it starts. The time is now for being your best you! You have to seek it and I can help! On a personal note I have a Chiweenie, and my hobbies are self/help, psychology, learning, reading, being near water, church or bible groups, and time with family and friends."

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